What is Natural Product!

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THE LANSEH FRUITPlants and living organisms produce a vast variety of chemical compounds with highly diverse structures. They are commonly known as “secondary metabolite”. Natural products usually have pharmacological and biological activity; so, found its uses in pharmaceuticals. Naturally occurring chemical compounds are of great significant for the life of mankind.

Sources of Natural Products

It has been seen from history, that earlier widely used chemical compounds were extracted from plants and animals. Later on their extraction from microbial organisms came into focus. As 90% of life form inhabits the oceans, so, now a day marine natural products are more focused. Marine life form could become a major source for the discovery of new drugs, marine ecosystem have a vast biological diversity. Many marine natural products have been marketed as drugs. Some marine natural products are in clinical trials for the treatment of cancer, analgesia, allergy, and cognitive diseases.

Chemical Compound of Plants

Phytochemicals

Phytochemicals are naturally occuring chemical compound of plants. Phytochemicals are responsible for color and organoleptic properties, like deep purple colour of blueberries and smell of garlic. Biologically significant phytochemicals are known as antioxidants. Phytochemicals have the ability to affect the diseases like cancer, stroke, metabolic syndrome, to reduce blood pressure, stop free radical reactions etc.

Currently many phtyochemicals are in clinical trials, like lycopene from tomato has been tested for cardiovascular diseases and prostate gland.

Some classes of phytochemicals are given below.

1- Carbohydrates

A carbohydrate is an organic compound which consist carbon hydrogen and oxygen. Carbohydrates are the most abundant biomolecules on planet earth. The empirical formula for carbohydrates is Cm(H2O)n  where  n ≥ 3. Carbohydrates perform numerous functions in living organisms. Monosaccharides are simplest carbohydrates, i-e glucose. Polysaccharides are complex carbohydrates; serve as storage of energy in the form of starch and glycogen.

2- Flavonoids

Flavonoids are a group of more than 4000 polyphenolic compounds that occur naturally in plants. Flavonoids refer to vitamin P. Major Part of plant material contain flavonoids. They have also been found in algae. Flavonoids are one of the diverse groups of compound. About 30 types of flavonoids have been identified in asteraceae. Flavonoids possess a great variety of biological activity at nontoxic concentration in organism.

Flavan

Flavan-4-ol

3- Alkaloids

Nitrogen containing naturally occuring compounds is called alkaloids. Some alkaloids have bitter taste. They are produced from a large variety of organisms, including bacteria, plants and animals. Many alkaloids are toxic to other organisms. In ancient times alkaloidal plants have been used by human for medication and recreational purposes; and as drugs, such as anaesthetic morphine and stimulant cocaine, caffine, nicotine, or the antimalarial drug quinine [13].

Caffine

Caffine

4- Terpenes

 

Terpenes are large and varied class of hydrocarbons produced primarily by plants and by some insects. The word terpenes is derived from” turpentine”. Terpenes and terpenoids are the primary constituents of essential oils. Vitamin A is an example of terpenes.

Terpenes are compounds that are built up from isoprene units. The isoprene units linked together from” head to tail” to form linear chains or they may be arrange to forms rings.

Terpenes are classified into following classes.  Monoterpenes (C 10), Sesquiterpene (CI5), Diterpenes (C20), Sesterterpenes (C25), Triterpenes (C30), Carotenoids (C40).

Hemiterpenes consist of a single isoprene units e.g isovaleric acid.

Monoterpenes consist of two isoprene units examples of monoterpenes are gerainol, citral and limonene. Limonene is obtained from lemon.

isoprene units

                                           Geraniol                                            Citral

Sesquiterpene consist of three isoprene units. e.g Farnesol.

Diterpenes are composed of four isoprene units. e.g Cafestol, cembrene. Diterpenes are biologically important compounds such as phytol, retinol, and retinal.

Sesterterpenes consist of five isoprene units.

Triterpenes consist of six isoprene units. The linear triterpenes is sequalene that is major constituent of shark liver oil.

Tetraterpenes consist of eight isoprene units. Biologically important tetraterpenes include acyclic lycopene, the monocyclic gamma-carotenes and bicyclic alpha and beta carotenes.

Polyterpenes contains long chains of many isoprene units. Natural rubber contains polyisoprene units in which double bonds are cis.

5- Steroids

Steroids are also triterpenoid compounds. They are naturally occurring lipids. It consists of characteristic arrangement of four cycloalkane rings that are fused to each other Cholesterol is an example of sterol hormone. Other steroid hormone involves female hormone progesterone and estrogens that are responsible for sexual characteristics. Androgens and testosterone is male sexual hormone.

6- Saponins

Saponins are secondary metabolites. Saponins are found in medicinal plants. They are also produced by holothurians. Almost 59 triterpene glycosides are reported. Several saponins are shared by species but others are specific. Saponins act as a means of defence in sea cucumber and posses a wide range of pharmacological effects. Like soap, saponins form leather on mixing with water. , The structure of saponins are based on lanosterol type triterpene with a distinctive D-ring with fused gamma lactone skeleton and a carbohydrate chain containing up to six sugar residues such as glucose (Glc), 3-O-methylglucose(MeGlc), quinovose(Qui),and xylose(Xyl).

7- Tannins

Tannins are polyphenols sometimes called plant polyphenols; originally the name tannin was given to plant extract exhibit astringency. Tannins are different from other plant polyphenols on the basis of following properties

  1. Binding to protein
  2. Basic compounds
  3. Pigments
  4. Large molecular compounds and metallic ions
  5. Anti oxidant activities.

Tannins are found in wide range of plant species. They are classified into two major groups:

  1. Hydrolysable
  2. Condensed tannins

Tannins

Gallic acid                                    Flavones

Hydrolysable tannin              Non Hydrolysable tannin

8- Phenylpropanoid

Naturally occuring compound possessing three carbon chain attached to the ring are called phenylepropanoid. i-e Cinnamic Acid.

Medicinal Uses

Silybum marianum has been used for medicinal from nearly two centuries ago. It is used to stimulate lactation in nursing mothers, in liver disorder and in treatment of gallbladder. Silymarin a flavonoid complex is extracted from the seed. Silybin that is antioxidant is part of chemical structure of silymarin. Silybin block the liver toxin from entering into liver, and stimulate regeneration and formation of new liver cell. Milk thistle is also used to minimize the side effect of cancer therapy.

It is also used in lowering cholesterol level. It is used to reduce insulin in peoples with type 2 diabetes. Reduce the growth of cancer cell in breast cancer, cervical and prostate cancer.

Photo Courtesy of: Wiki

Research Work:

Fariha Arif is brilliant student of University of Punjab, Lahore. She done this search work entitled “Estimation And Isolation Of Triacontanoic Acid From The Whole Plant Of Silybum Marianum”.  She done this thesis for the requirement for the degree of BS in chemistry. Click here to down load her complete thesis.

Mike Smith

Mike Smith is founder and editor of analyzeronline.com. His main objective is to provide informative articles, reviews and analysis of everyday life topics to his readers that help them to make their life more easier and more healthier.